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Tumor necrosis factor α, in the secreted as well as membrane-associated (mTNFα) form, represents a cytotoxic effector mechanism of activated macrophages; in contrast, direct evidence of the mTNFα involvement in cytotoxic T lymphocyte (CTL)-mediated lysis has not yet been obtained. We observed that following activation with anti-CD3 monoclonal antibody (mAb), both cloned CTL and peritoneal exudate...
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