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Plackett–Burman multifactorial design and the consequent response surface methodology (RSM) were used to improve the streptolydigin yield in a newly isolated strain Streptomyces lydicus AS 4.2501 with a dramatic streptolydigin increase of 18.6%. Also propionate's role as a precursor for the streptolydigin biosynthesis was for the first time practically validated. The results from the Plackett–Burman...
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