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Key points
Low weight at birth increases the risk of developing chronic diseases in adulthood
A diet that is high in salt is known to elevate blood pressure, which is a major risk factor for cardiovascular and kidney diseases
The present study demonstrates that growth restricted male rats have a heightened sensitivity to high dietary salt, in the context of raised systolic blood pressure, reduced...
Inhibition of the renin-angiotensin system in early postnatal life is a potential therapeutic approach to prevent long-term cardiovascular and kidney diseases in individuals born small. We determined the long-term effects of juvenile losartan treatment on cardiovascular and kidney function in control male rat offspring and those exposed to uteroplacental insufficiency and born small. Bilateral uterine...
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