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BackgroundPattern recognition receptors (PRRs) orchestrate the innate immune defence in human biliary epithelial cells (BECs). Tight control of PRR signalling provides tolerance to physiological amounts of intestinal endotoxins in human bile to avoid constant innate immune activation in BECs.
AimsWe wanted to determine whether inappropriate innate immune responses to intestinal endotoxins contribute...
Background: Development of end‐stage liver and graft disease is suspected to be partially determined by the individual genetic background. Mannose‐binding lectin (MBL) is an important immunomodulatory factor, which is supposed to be involved in complement activation and oncogenesis. Genetic polymorphisms of MBL‐2 alter MBL functionality. The aim of our study was to determine the prevalence of MBL‐2...
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