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This study tested the hypothesis that deficits in γ-aminobutyric acid type A (GABA A ) receptor function might create a vulnerability to the psychotogenic and perceptual altering effects of serotonergic (5-HT 2A/2C ) receptor stimulation. The interactive effects of iomazenil, an antagonist and partial inverse agonist of the benzodiazepine site of the GABA A receptor complex,...
Background: Several lines of evidence derived from imaging and postmortem studies suggest that schizophrenia is associated with hyperactivity of dopamine function and deficiency in serotonin (5-HT) function. The aim of this study was to investigate potential alterations of striatal dopamine transporters (DAT) and brainstem serotonin transporters (SERT) density in schizophrenia.Methods: Striatal DAT...
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