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Emerging experimental evidence suggests that activation of Toll‐like receptor 3 (TLR3) by its agonist polyinosinic polycytidylic acid (poly‐ICLC) protects neurons against cerebral ischemia, but the underlying mechanisms remain largely unknown. In the brain, TLR3 is mostly expressed in glial cells. Therefore, we assess the hypothesis that TLR3 activation in microglia is required for neuroprotection...
Granulocyte colony-stimulating factor (G-CSF) is a neuroprotective agent and activates endothelial proliferation and bone marrow stem cell mobilization. We studied the effect of G-CSF on angiogenesis and neurological recovery after focal cerebral ischemia. After the induction of transient focal ischemia in rats, G-CSF (50 μg/kg/day, i.p.) or PBS was administered for 3 days. We evaluated the functional...
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