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Triphenylphosphonium functionalization of a conjugated oligoelectrolyte (COE) with a stilbene core improved its spectrum of activity to include ESKAPE pathogens and mycobacteria while crucially retaining the membrane‐perturbing mode of action characteristic of COEs. The efficacy of the lead compound in vivo highlights the potential of the COE molecular platform for designing more effective antibiotics...
Conjugated oligoelectrolytes (COEs) are an emerging class of amphiphilic antimicrobial compounds with a modular molecular framework suitable for simple chemical derivatization. Here, a series of COE derivatives with a stilbene‐conjugated segment and triphenylphosphonium (TPP) pendant groups was designed and synthesized to understand how lipophilic cationic groups impact antimicrobial activity. In...
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