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Background
Human papillomavirus‐associated head and neck squamous cell carcinoma (HPV + HNSCC) occurs in the oropharynx (HPV + OPSCC), sinonasal cavity (HPV + SNSCC), and nasopharynx (HPV + NPC). Circulating tumor HPV DNA (ctHPVDNA) is an accurate tool for diagnosis, treatment monitoring, and recurrence detection. An emerging challenge with ctHPVDNA is that ~7.4% of HPV + HNSCC patients develop synchronous...
BackgroundWith prior studies having looked at unselected cohorts, we sought to explore the mutational landscape in a high‐risk group of head and neck squamous cell carcinoma (HNSCC) tumors.
MethodsA multiplexed polymerase chain reaction (PCR) assay evaluating 68 loci in 15 genes was performed on 64 patients with high‐risk HNSCC. Because of the frequent PIK3CA and AKT1 mutations in patients with oropharyngeal...
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