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The meniscus plays a critical role in maintaining the homeostasis, biomechanics, and structural stability of the knee joint. Unfortunately, it is predisposed to damages either from sports‐related trauma or age‐related degeneration. The meniscus has an inherently limited capacity for tissue regeneration. Self‐healing of injured adult menisci only occurs in the peripheral vascularized portion, while...
The meniscus has complex biomechanical functions endowed by the hierarchical fibrous structure of its extracellular matrix (ECM), which plays a central role in protecting the knee joint. However, it is challenging to recapitulate the ECM structure of the meniscus. Herein, we used electrospinning to prepare various scaffolds with distinct nanofibrous structures to approximate that of the heterogeneous...
Galactosylated chitosan‐hydroxypropyltrimethylammonium (gal‐HTCC) was synthesized by galactosylating and quaternizing chitosan to endue chitosan with targeting specificity for potential applications as gene vectors. The composition and physicochemical properties of gal‐HTCC were characterized by FT‐IR, 1H NMR, elemental analysis, X‐ray diffraction, and turbidity measurement. It was found that water‐soluble...
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