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Objectives/Hypothesis
Mesenchymal stem cells (MSCs) hold therapeutic promise for vocal fold scar, yet the precise mechanism(s) underlying tissue level changes remain unclear. We hypothesize that MSCs interact with native fibroblasts to favorably affect healing. Furthermore, we hypothesize that these interactions vary based on MSC source.
Methods
Vocal fold fibroblasts (VFFs), adipose‐derived stem...
Objectives/Hypothesis
To optimize decellularization of porcine vocal folds (VF) and quantify human bone marrow‐derived mesenchymal stem cell (BM‐MSC) interactions with this matrix to provide a foundation for regenerative approaches to VF repair.
Study Design and Methods
Vocal folds were dissected from porcine larynges and three decellularization protocols were compared, each consisting of washes...
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