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Perinatal hypoxic–ischemic (HI) is a major cause of brain injury in the newborn, and there is a lack of effective therapies to reduce injury-related disorders. The aim of the present study was to evaluate the effect of a combination of ephedrine and hyperbaric oxygen (HBO) on neonatal hypoxic–ischemic brain injury. 7-day-old Sprague–Dawley rat pups were randomly divided into sham operation, HI, ephedrine,...
Objective: Study the effect of ephedrine on neural plasticity of hypoxic ischemic brain damaged (HIBD) in neonatal rats, and explore the underlying molecular mechanism. Methods: 60 Sprats suffered from HIBD (7 days old) were randomly divided into ephedrine group, d-amphetamine (d-AMPH) group, cytidine triphosphate (CTP) group, ganglioside (GM1) group, and spontaneous recovery group. Using immunohistochemical...
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