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Abnormal silencing of fibroblast growth factor (FGF) signaling significantly contributes to joint dysplasia and osteoarthritis (OA); However, the clinical translation of FGF18‐based protein drugs is hindered by their short half‐life, low delivery efficiency and the need for repeated articular injections. This study proposes a CRISPR/Cas9‐based approach to effectively activate the FGF18 gene of OA...
Because the tumor‐draining lymph nodes (TDLNs) microenvironment is commonly immunosuppressive, oncolytic microbe‐induced tumor antigens aren't sufficiently cross‐primed tumor specific T cells through antigen‐presenting cells (e.g., dendritic cells (DCs)) in TDLNs. Herein, this work develops the micro‐to‐nano oncolytic microbial therapeutics based on pyranose oxidase (P2O) overexpressed Escherichia coli...
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