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Background
Occlusive thrombi are not homogeneous in composition. The core of a thrombus is rich in activated platelets and fibrin while the outer shell contains resting platelets. This core is inaccessible to plasma proteins. We produced a fusion protein (targeted SERPIN–TaSER), consisting of a function‐blocking VHH against glycoprotein Ibα (GPIbα) and a thrombin‐inhibiting serine protease inhibitor...
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