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Circular RNA‐synaptosome associated protein 47 (circ‐SNAP47; Hsa_circ_0016760) is oncogenic in non‐small‐cell lung cancer (NSCLC); however, its role is undescribed in cis‐diamminedichloroplatinum II (DDP) resistance. We attempted to investigate its expression, role and mechanism in DDP‐tolerant NSCLC. As a result, circ‐SNAP47 expression was upregulated in human DDP‐tolerant NSCLC tissues and cells,...
Microcystin‐LR (MC‐LR) has been regarded as a hepatotoxin, which can cause cytoskeletal reorganization, especially of the actin filaments. However, the underlying mechanisms remain unclear. In this study, whether MC‐LR could induce microfilaments disruption was verified in the normal human liver cell line HL7702; and then the transcription, translation, and phosphorylation levels of major microfilament‐associated...
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