Search results for: Wenjun Guo
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Integrin-Specific Activation of Rac Controls Progression through the G 1 Phase of the Cell Cycle
Molecular Cell > 2001 > 8 > 1 > 115-127
Adhesion to fibronectin through the α5β1 integrin enables endothelial cells to proliferate in response to growth factors, whereas adhesion to laminin through α2β1 results in growth arrest under the same conditions. On laminin, endothelial cells fail to translate Cyclin D1 mRNA and activate CDK4 and CDK6. Activated Rac, but not MEK1, PI-3K, or Akt, rescues biosynthesis of cyclin D1 and progression...
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