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To elucidate whether new proteases are involved in the processing of amyloid precursor protein (APP), we examined catalytically active ADAM12 and ADAM19 as candidates α-secretases. The overexpression of ADAM19 in HEK293 cells resulted in an increase in sAPPα. Therefore, we suggest that ADAM19 has a constitutive α-secretase activity. We examined regulated α-secretase activity by adding phorbol 12-myristate...
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