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The action of diuretic furosemide on the GABA A receptor was studied in acutely isolated Purkinje cells using the whole-cell recording and fast application system. Furosemide blocked stationary component of GABA-activated currents in a concentration-dependent manner with IC 50 value > 5 mM at -70 mV. The inhibition was rapid in the onset, fully reversible and did not require...
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