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The modulation of BmK AS, a neurotoxic polypeptide from scorpion Buthus martensi Karsch, on the voltage-gated Na + channels has been investigated in the B104 neuroblastoma cell line by whole-cell patch clamping. It was found that the whole Na + currents and tetrodotoxin-resistant Na + current were depressed in a biphasic manner and both steady-state activation and inactivation...
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