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Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by polysomnography‐confirmed REM sleep without atonia and dream‐enacting behaviors. This disorder is considered a prodromal syndrome of alpha‐synucleinopathies like Parkinson's disease (PD), where it affects more than 50% of PD patients. The underlying pathology of RBD has been generally understood to involve the...
Background:Pathological gambling may occur in Parkinson's disease (PD) as a complication of dopaminergic therapy. Neuroimaging studies have suggested an abnormal dopamine transmission within the reward system, but the changes in the neural network characterizing PD patients with pathological gambling have never been investigated.
Methods:Thirty PD patients (15 with active gambling and 15 matched...
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