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AimTo examine whether protein kinase C (PKC) and associated downstream mechanisms are involved in hyperglycaemia (HG)‐evoked blood–brain barrier (BBB) damage.
MethodsThe activities of total PKC (Peptag assay), NADPH oxidase (lucigenin assay) and matrix metalloproteinase‐2 (MMP‐2; gelatin zymography) were measured in human brain microvascular endothelial cells (HBMEC) exposed to normoglycaemia (5...
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