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The free Ca 2+ concentration within the mitochondrial matrix ([Ca 2+ ] m ) regulates the rate of ATP production and other [Ca 2+ ] m sensitive processes. It is set by the balance between total Ca 2+ influx (through the mitochondrial Ca 2+ uniporter (MCU) and any other influx pathways) and the total Ca 2+ efflux (by the mitochondrial Na...
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