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Histone acetyl transferases (HATs) are important histone modifiers that affect critical cellular processes like transcription, DNA replication and repairs through highly dynamic chromatin remodelling. Our earlier studies recognized LdHAT1 as a substrate of the S‐phase cell cycle kinase LdCyc1‐CRK3 from Leishmania donovani. Here, we confirm through site‐directed mutagenesis that RXL‐like cyclin‐binding...
We have cloned and sequenced a DNA fragment (~1 kb) containing a complete open reading frame from a cDNA library of Leishmania donovani promastigotes. The alignment of the derived polypeptide sequence and the modeling studies revealed that the protein is highly homologous to the mammalian cyclins having conserved cyclin box and substrate-docking motif. Northern blot analysis of the RNA isolated from...
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