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Heterozweikernige Metalloenzyme bilden eine bedeutende Klasse von Metalloproteinen, bei denen jedoch die Bestimmung der Positionen der Metallionen schwierig sein kann. Hier beschreiben wir ein neues NMR‐Verfahren, das Pseudokontaktverschiebungen (PCS) nutzt, um die Position von Metallionen ohne Annahmen über die koordinierenden Liganden zu ermitteln. Die Methode wird anhand des zweikernigen [FeZn]‐Komplexes...
Mice heterozygous for the N-ethyl-N-nitrosourea-induced Waved-5 (Wa5) mutation, isolated in a screen for dominant, visible mutations, exhibit a wavy coat similar to mice homozygous for the recessive Tgfawa1 or Egfrwa2 alleles. In this study, we show that Wa5 is a new allele of Egfr (EgfrWa5) containing a missense mutation within the coding region for the highly conserved DFG motif of the tyrosine...
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