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Recent studies highlight the role of DNA methylation in the pathogenesis of Parkinson's disease (PD). However, there is a paucity of studies exploring the role of blood-based DNA methylation in PD. We aimed to explore identifiable epigenetic biomarkers for PD by analyzing the methylation status of α-synuclein (SNCA) and leucine-rich repeat kinase 2 (LRRK2) in leukocytes.Bisulfite Specific PCR-based...
BackgroundGenome‐wide association studies (GWAS) have identified numerous single‐nucleotide polymorphisms (SNPs) that can modulate the risk of developing Parkinson's disease (PD).
MethodsWe investigated the association of previously identified loci in a Mainland Chinese population to identify a possible ethnic‐specific effect with GWAS analysis. Seventeen SNPs were genotyped from those loci using...
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