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Synergistic Immunotherapy
In article number 2300232, Xu‐Man Chen, Zhiyang Liu, Quan Li, and co‐workers report a membrane‐targeted photosensitive dimer, which is found to exhibit superior antitumor immnotherapy under synergistic photodynamic and photothermal effect. In hypoxic tumor tissue, photodynamic therapy can effectively generate type‐I reactive oxygen species, leading to pyroptosis. The remarkable...
Overcoming the resistance to apoptosis and immunosuppression of tumor cells is a significant challenge in augmenting the effect of cancer immunotherapy. Pyroptosis, a lytic programmed cell‐death pathway unlike apoptosis, is considered a type of immunogenic cell death (ICD) that can intensify the ICD process in tumor cells, releasing dramatically increased tumor‐associated antigens and damage‐associated...
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