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Tonic and phasic rapid eye movement (REM) sleep seem to represent two different brain states exerting different effects on epileptic activity. In particular, interictal spikes are suppressed strongly during phasic REM sleep. The reason for this effect is not understood completely. A different level of synchronization in phasic and tonic REM sleep has been postulated, yet never measured directly. Here...
J. Neurochem. (2010) 115, 92–101.
AbstractProlonged seizures activate members of the Bcl‐2 homology domain 3‐only sub‐group of the Bcl‐2 protein family, which are essential for initiation of apoptosis signaling. Bid is a potent pro‐apoptotic Bcl‐2 homology domain 3‐only protein, which upon proteolytic activation translocates to mitochondria to promote activation of the Bax/Bak sub‐group of the pro‐apoptotic...
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