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Glycolic acid, an alpha-hydroxy acid derived from fruit and milk sugars, has been commonly used as a cosmetic ingredient since it was known to have photo-protective and anti-inflammatory effects, and anti-oxidant effect in UV-irradiated skin. However, little has been known about the functional role of glycolic acid on UV-induced skin tumorigenesis. We previously found that glycolic acid inhibited...
In this study, we identified a new mechanism for the anti-proliferation of HCT15 colorectal cancer cells by troglitazone (TRO). Treating HCT15 cells with 20μM of TRO transiently increased extracellular signal regulated kinase (ERK) activity within 15min, and this subsequently induced p21 Cip/WAF1 cell cycle regulator and localized in the nucleus. Raf-1 modification...
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