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Periodontal ligament is considered a rich source of mesenchymal stem cells for pulp regeneration. This study investigated the effect of iloprost, a prostacyclin analog, on cell proliferation and the expression of angiogenesis-related genes in human periodontal ligament cells (hPDLs) in vitro. The hPDLs were treated with 10−9–10−6 M iloprost for 1, 6 and 24 h. Cell proliferation was determined by an...
Prostacyclin (PGI 2 ) is a biomolecule capable of enhancing angiogenesis and cellular proliferation.We investigated the influence of a PGI 2 analogue (iloprost) on dental pulp revascularization in vitro and in vivo by using human dental pulp cells (HDPCs) and a rat tooth injury model, respectively. Iloprost stimulated the human dental pulp cell mRNA expression of vascular endothelial...
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