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ObjectiveChronic cerebrospinal venous insufficiency (CCSVI) has been implicated in the pathophysiology of multiple sclerosis (MS). We sought to determine whether neurosonography (NS) provides reliable information on cerebral venous outflow patterns specific to MS.
MethodsThis was a single‐center, prospective case–control study of volunteer MS and non‐MS participants. A neurosonologist, blind to the...
ObjectiveA double‐blind, randomized, controlled study was undertaken to determine whether combined use of interferon β‐1a (IFN) 30μg intramuscularly weekly and glatiramer acetate (GA) 20mg daily is more efficacious than either agent alone in relapsing–remitting multiple sclerosis.
MethodsA total of 1,008 participants were randomized and followed until the last participant enrolled completed 3 years...
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