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In vivo biomedical studies using animals can provide high similarity to the physiological conditions in humans. However, it is difficult to observe the molecular processes in the whole animals. On the contrary, in vitro studies could control the environmental factors in experiments but usually are difficult to reflect the complex physiological responses existing in vivo. In this paper, we report our...
A lobule-mimetic cell-patterning technique for on-chip reconstructing centimeter-scale liver tissue of heterogeneous hepatic and endothelial cells via the enhanced field-induced dielectrophoresis (DEP) trap is demonstrated and reported. By mimicking the basic morphology of the liver tissue, the classic hepatic lobule, the lobule-mimetic-stellate-electrodes array is designed for cell patterning via...
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