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In human osteoblasts, the effect of the widely prescribed cyclooxygenase-2 inhibitor celecoxib on intracellular Ca 2+ concentrations ([Ca 2+ ] i ) and cell proliferation was explored by using fura-2 and the tetrazolium assay, respectively. Celecoxib at concentrations greater than 1μM caused a rapid rise in [Ca 2+ ] i in a concentration-dependent...
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