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In this study, a series of multipotent phenylthiazole–tacrine hybrids (7a–7e, 8, and 9a–9m) were synthesized and biologically evaluated. Screening results showed that phenylthiazole–tacrine hybrids were potent cholinesterase inhibitors with pIC 50 (−logIC 50 ) value ranging from 5.78±0.05 to 7.14±0.01 for acetylcholinesterase (AChE), and from 5.75±0.03 to 10.35±0.15 for butyrylcholinesterase...
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