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Biliary cholesterol secretion helps maintain cholesterol homeostasis; it is regulated by the cholesterol exporter adenosine triphosphate–binding cassettes G5 and G8 (ABCG5/G8) and the cholesterol importer Niemann–Pick C1-like 1 (NPC1L1). We studied another putative regulator of cholesterol secretion into bile, Niemann–Pick C2 (NPC2)—a cholesterol-binding protein secreted by the biliary system—and...
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