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Patatin-like phospholipase domain containing protein 1 (PNPLA1) mutations have been identified to be associated with autosomal recessive congenital ichthyosis (ARCI) in recent years. However, its molecular characters have not been achieved until now. In the current study, the full length coding cDNA sequence of mouse PNPLA1 (mPNPLA1) was identified firstly. There were several putative transmembrane...
Variability in patient drug responses is observed with increasing frequency, necessitating the establishment of causal associations between factors and drug response phenotypes. This individual variability can be caused by genetic factors and environmental factors (ENFs). Although pharmacogenetics has been instrumental in describing genetic variations, frameworks for understanding the association...
Human cancers often display aberrant patterns of differentiation. By appropriate chemical manipulation, specific human cancers, such as human melanoma, leukemia and neuroblastoma, can be induced to lose growth potential irreversibly and terminally differentiate. Treatment of HO-1 human melanoma cells with a combination of recombinant human fibroblast interferon (IFN-β) and the antileukemic compound...
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