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Peroxisome proliferator‐activated receptor gamma coactivator‐1α (PGC‐1α) is a transcriptional coactivator involved in the regulation of mitochondrial biogenesis and cell defense. The functions of PGC‐1α in physiology of brain mitochondria are, however, not fully understood. To address this we have studied wild‐type and transgenic mice with a two‐fold overexpression of PGC‐1α in brain neurons. Data...
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