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Activation of death receptor‐5 (DR5) leads to the formation of death‐inducing signaling complex (DISC) for apoptotic signaling. TRA‐8, a DR5 specific agonistic antibody, has demonstrated significant cytotoxic activity in vitro and in vivo without inducing hepatotoxicity. Calmodulin (CaM) that is overexpressed in breast cancer plays a critical role in regulating DR5‐mediated apoptosis. However, the...
The purpose of this study was to evaluate the cytotoxicity of a death receptor 5 (DR5) targeting monoclonal antibody (TRA-8) in primary ovarian cancer specimens utilizing a tissue slice technique that allows for assessment of anti-tumor activity in a three-dimensional ex vivo model.Nineteen primary ovarian tumor specimens were obtained at the time of cytoreductive surgery and tumor slices were prepared...
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