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We describe neuronal density, neuroplasticity and vascular remodelling and their association with spatial memory in young (4–6 months), middle-aged (9–11 months) and aged (18–20 months) rats of both genders. The neuronal density was reduced in the hippocampus of middle-aged and aged rats, particularly in male rats. However the loss of spatial memory investigated using the Morris water maze, T-maze...
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