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Previously, we have shown that human DNA polymerase (Pol) η has two functional PCNA‐binding motifs, PIP1 and PIP2, and that a C‐terminal deletion of Polη that lacks the ubiquitin‐binding UBZ domain and the PIP2 domain but retains the PIP1 domain promotes normal levels of translesion synthesis (TLS) opposite a cis‐syn TT dimer in human cells. Here, we identify two PIP domains in Polκ and show that...
Expression of gastrin and cholecystokinin 2 (CCK2) receptor splice variants (CCK2R and CCK2i4svR) are upregulated in human colonic adenomas where they are thought to contribute to tumor growth and progression. To determine the effects of ectopic CCK2 receptor variant expression on colonic epithelial cell growth in vitro and in vivo, we employed the non‐tumorigenic colonic epithelial cell line, NCM356...
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