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To determine whether or not the methylation status of blood leukocyte DNA can be used as a surrogate marker of the risk for cancer, we quantitatively determined the methylation levels of insulin‐like growth factor 2 (IGF2) and TUSC3 in 299 gastric cancer cases, and 299 age‐ and gender‐matched controls. The IGF2 methylation levels in blood leukocyte DNA of the cases were lower than those of the healthy...
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