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Time-of-Flight (TOF) PET data determines the attenuation map up to a constant. MLAA (Maximum Likelihood Activity and Attenuation Estimation) was proposed for this purpose. However, in real systems the estimated attenuation map usually results in bias and artifacts, due to various factors such as non-uniform timing resolution, detector timing drift, and biased scatter estimation. Moreover, MLAA has...
The goal of this study is to develop and evaluate two 4D statistical iterative image reconstruction (SIIR) methods with respiratory motion (RM) and cardiac motion (CM) compensation for improving the detection of motion defects in 4D gated cardiac PET. The first 4D SIIR method, motion correction after reconstruction (MCAR) was developed previously, where the dual RM&CM compensation was achieved...
Respiratory motion is one image degradation factor that affects the resolution and may cause artifacts in PET imaging. Respiratory gating technique is able to reduce the blurring effects but results in higher noise level. Conventional motion correction methods that model motion effects during or after image reconstruction not only increases reconstruction time, but also requires a gated or blurred...
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