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AimTo summarize the collective in vitro, in vivo and clinical evidence of the involvement of the receptor activator of NF‐κB ligand (RANKL)‐osteoprotegerin (OPG) system, a system of two molecules controlling osteoclast differentiation and hard‐tissue resorption, in pulpal and periapical pathophysiology.
MethodologyA systematic search related to RANKL and/or OPG and pulp or periapical disease was...
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