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Objective
To explore and elucidate the formation of niacinamide (NIA) by‐products during in vitro skin permeation studies using liquid chromatography coupled to mass spectrometry (LC‐MS) analysis.
Methods
Porcine skin permeation studies of various NIA formulations were conducted using Franz diffusion cells for a period of 24 hours. NIA by‐products were identified by LC, extracted and further qualitatively...
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