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Previously a novel and efficient one-pot method has been developed for the synthesis of 1-substituted-3,4-dihydro-β-carbolines starting from tryptamine and a wide variety of carboxylic acids. The first reaction step was the acylation of tryptamine leading to the corresponding acyltryptamines, followed by a ring-closure step affording the tricyclic target molecules. In the present paper, possible mechanisms...
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