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Several studies on the prediction of the LC retention time of tryptic peptides have been applied on protein identification for the proteomic analyses. In this study a proteomic method was developed based on prediction of retention time of chromatography and mass to charge value. With the conversion of normalized elution time into predicted retention time, tryptic peptides of E. coli cytosol were analyzed...
It's well known that irreversible cross-linked complexes between proteins, produced by formaldehyde interacting with free amino or amide groups to form Schiff s base, are formed in diabetes and aging patients. To identify such specific modified peptides as biomarkers for clinical diagnose of diabetes and AD, cross-linkage of formaldehyde with human serum albumin (HSA) was analyzed by LC/ESI/MS in...
AGEs are a heterogeneous group of proteins that have been shown to react with the amino group of the N-terminal amino acid residue and the side-chains of arginine and lysine residues. Glycation induced protein modifications has been implicated in diabetes and its associated complications like nephropathy, retinopathy, aging as well as in atherosclerosis, Alzheimer's and Parkinson's diseases. The identification...
Formaldehyde, a well-known environmental toxic hazard, has been found to produce endogenously via semicarbazide-sensitive amine oxidase-catalyzed oxidative deamination of methylamine. In diabetes, the activity of SSAO has been found to increase with a subsequent increase in endogenous formaldehyde production. It has been postulated that SSAO-induced production of formaldehyde may be involved in the...
Advanced glycation end products (AGEs) are a heterogeneous group of proteins that have been modified with glucose or carbohydrates adducts, and are thought to be responsible for many complications of diabetes and aging. Free amino groups of proteins react slowly with reducing sugars such as glucose by the glycation or Maillard reaction, initially forming Schiff bases, which undergo rearrangement to...
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