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Parkinson's disease (PD) is a common neurodegenerative disorder in aging and loss of dopamine (DA) in nigrostriatal system is an important character of PD. Animal models is very useful in the research of pathogenesis of PD. However, the DA content is not always decreased in the nigrostriatal system of these models as the situation of PD patients. Viral vector-based PD models in animals were newly...
Post-digestion 18O labeling technique and comparative proteomics are used to carry out a large-scale proteome characterization for α-synuclein overexpression transgene mouse model. Proteins of transgene mice brain were labeled by 18O, but not for proteins of control. Spectrum Mill software give the specific value of H/L of every protein detected by HPLC/ESI-QTOF, which reflect the difference of protein...
Parkinson's disease (PD) is a multifactorial, neurodegenerative disease where etiopathogenesis are not fully understood. Mutations in α-Synuclein (α-Syn) were the first genetic defect linked to PD. They are deposited in Lewy bodies (LBs) characteristic for PD. Some experiments had showed that A30P mutant a-Syn have high toxicity than wide-type α-Syn. Here we used A30Pα-Syn transgenic mice model to...
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