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We investigated the association of 14 polymorphisms in the endothelial nitric oxide synthase gene (NOS3) with ankle brachial index (ABI) in non-Hispanic white hypertensives belonging to hypertensive sibships. Subjects (n=659, mean age 61±9 years, 54% women) underwent measurement of ABI using a standard protocol, and the lowest of 4 ABI values was used in the analyses. Non-synonymous SNPs with a minor...
Little is known about the genetics of peripheral arterial disease (PAD). We performed linkage analyses to identify genomic regions that influence ankle–brachial index (ABI), a measure of PAD, in 1310 African Americans (AA) (mean age 62±9 years) and 796 non-Hispanic whites (NHW) (mean age 58±9 years) belonging to hypertensive sibships. ABI was determined at two sites in each lower extremity and the...
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