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Variation in genes associated with serum levels of proteins may be useful for examining specific disease pathways. Using data from a large study of colon cancer, we examine genetic variants in insulin, inflammation, estrogen, metabolizing enzymes, and energy homeostasis genes to explore associations with microsatellite instability (MSI), CpG Island methylator phenotype (CIMP), mutations of p53 in...
The genetic heterogeneity of colon cancer suggests that it is actually more than one disease, and perhaps represents a conglomeration of genetically different diseases which happen to occur in the same organ. The progressively more refined genetic definition of colon cancer has uncovered and/or strengthened heretofore obscured associations with clinicopathologic features and risk factors and has led...
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