The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Follicular helper T (TFH) cells are essential for inducing germinal centre (GC) reactions to mediate humoral adaptive immunity and antiviral effects, but the mechanisms of TFH cell differentiation remain unclear. Here, we found that the hippo kinase MST1 is critical for TFH cell differentiation, GC formation, and antibody production under steady‐state conditions and viral infection. MST1 deficiency...
CD8+ T cells play a crucial role in anti‐tumour immunity, but they often undergo exhaustion, which affects the anti‐tumour activity of CD8+ T cells. The effect and mechanism of exhausted CD8+ T cells have become the focus of anti‐tumour immunity research. Recently, a large number of studies have confirmed that long‐term antigen exposure can induce exhaustion. Cytokines previously have identified their...
Follicular T helper (TFH) cells are specialized T cells that support B cells, which are essential for humoral immunity. TFH cells express the transcription factor B‐cell lymphoma 6 (Bcl‐6), chemokine (C‐X‐C motif) receptor (CXCR) 5, the surface receptors programmed cell death protein 1 (PD‐1) and inducible T‐cell costimulator (ICOS), the cytokine IL‐21 and other molecules. The activation, proliferation...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.