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Ischemic stroke is currently treated with thrombolytic therapy with a drawback to induce hemorrhagic transformation (HT) if applied beyond its relatively narrow treatment time window. The present study was designed to examine the role of IMM‐H004, a derivative of coumarin, in recombinant tissue plasminogen activator (tPA)‐induced HT. Rats subjected to 6 h of thromboembolic occlusion or middle cerebral...
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