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Zinc (Zn2+) is considered to be one of the factors aggravating brain damage after cerebral ischemia. Since Zn2+ activates microglia, immune cells in the brain, this metal is proposed to modulate neuroinflammatory responses in the post-ischemic brain. Interleukin (IL)-23 is a heterodimeric cytokine composed of the p19 subunit unique to IL-23 and the p40 subunit common to IL-12. IL-23 has been shown...
Expression of cytochrome P450 3A4 (CYP3A4) is induced by 1,25-dihydroxyvitaminD3 (1,25(OH)2D3) in Caco-2 cells. However, since a typical vitamin D responsive element has not been found in the 5 ′ -flanking region of the CYP3A4 gene, the mechanism of 1,25(OH) 2 D 3 -induced CYP3A4 mRNA expression is poorly understood. In the present study, we demonstrated that vitamin D receptor...
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